KLINISCHE PSYCHOLOGIE UND PSYCHOTHERAPIE TU DRESDEN: CELOS
Institute of Clinical Psychology and Psychotherapy:
Center for Clinical Epidemiology and Longitudinal Studies (CELOS)
Prof. K. Beesdo-Baum, Dr. L. Pieper, Prof. F. Jacobi, Dr. M. Höfler, Prof. H.-U. Wittchen
- To facilitate, promote and to conduct clinical and behavioural epidemiological studies with particular focus on longitudinal and family genetic studies in the community, primary care and clinical cohorts.
- To provide and develop state of the art methods for use in clinical epidemiological and longitudinal research including survey and laboratory-based assessment techniques and diagnostic tools.
- To provide biometric and statistical expertise with particular focus on causal-analytic statistical methods within complex designs.
- To provide state of the art expertise in sampling, survey methodology and field work procedures, data collection and data bank management.
The Center for Clinical Epidemiology and Longitudinal Studies (CELOS) is laboratory platform of the Institute of
Clinical Psychology and Psychotherapy in the Faculty of Mathematics and Natural Sciences (Director: Professor
Dr. H.-U. Wittchen), located on 156 sqm (8 rooms, adjacent to the Institute). It includes field work-, CATI- and
CAPI-administration labs and observation lab. The Center maintains close collaboration with the Institute of Clinical
Pharmacology and its Public Health Network (Director: Prof. Dr. Dr. W. Kirch). The CELOS center has extensive
experience in the management of large-scale data banks and multi-center longitudinal data sets (comprising blood
samples, genetic, clinical and experimental data with thousands of subjects). Concerning the statistical data processing
there is excellent expertise in sampling theory and weighting procedure, as well as statistical expertise, particularly
with regard to modeling causal pathways, psychometric analyses, sensitivity and specificity analyses and
complex multivariate statistics.
CELOS survey lab:
The survey lab is part of the Celos centre. Its purpose is the field
work and computer-assisted telephone interviewing. It consists
of 10 workstations in two rooms. Each work station is separated
by partition panels and equipped with a telephone (with headset)
connected via USB to a desktop PC or Laptop. Phones are completely
controlled by PC, therefore hand-free calling is possible.
Calling and data entry runs with a Microsoft Access application.
Collected data can be exported in several file formats and further
data processing with standard statistical software (Stata) is possible.
Work groups and personnel:
Diagnostic tools and psychometrics: Dr. Lars Pieper, Prof. Dr. Frank Jacobi
Computer assisted interviewing (CAPI, CATI): Dipl.-Stat. Jens Siegert
Survey Lab (CATI): Dr. Lars Pieper
ESM: Andrew Gloster, PhD
Biometrics, statistics, data bank management:
Causal analytic designs and methods: Dr. Dipl.-Stat. Michael Höfler
Biometrical and statistical issues: Dr. Dipl.-Stat. Michael Höfler
E-CRF, databank management, informatics: Dipl.-Stat. Jens Siegert, Dipl.-Ing.(FH) Eckhard Schulz; Torsten Tille
Collaboration with the KKS Dresden
Field work unit:
Sampling and proband tracking: Dipl.-Psych. Simone Heinze
Monitoring: Dr. Lars Pieper
Quality Assurance: 3P Consulting, PD Dr. David Pittrow
Current and past Projects:
Major clinical epidemiological longitudinal studies of the centre:
1. Mental Health and Substance Abuse Studies:
- DfG Research Group “Learning and habitisation as predictors of the Development and Maintenance of Alcoholism”, Z-Project, n=1200 subjects in Dresden and Berlin, cross-sectional and longitudinal. Funding: DFG.
- Alcohol dependence in primary care in Europe (APC), 2400 patients in German primary care, 1500 personal interviews, cross-sectional and longitudinal. Funding: Lundbeck GmbH.
- German epidemiologic Health Survey (Deutscher epidemiologischer Gesundheitssurvey) DEGS - Zusatzsurvey psychische Gesundheit, 5000 patients in 120 sample points, personal interviewing; Funding: BMBF.
- Trauma and Stress-related disorders in German Soldiers with and without Foreign Deployment, n=1600 soldiers, cross-sectional and longitudinal. Funding: BMVg.
- Prevalence, 1-year incidence and symptom severity of mental disorders in the elderly: Relationship to impairment, functioning (ICF) and service utilisation (MentDis65+), Funding: EU.
- DSM-V dimensional measures for depression and anxiety. N=250, cross-sectional study.
- PanicNet: Improving CBT for panic by identifying the active ingredients and understanding the mechanisms of action – a multicenter study. 400 subjects, longitudinal. Funding: BMBF.
- Predictors, Moderators and Outcomes of Substitution Treatment (PREMOS), 2.694 patients; Funding: BMBF.
- Improving Alzheimer Demetia Treatment: Epidemiological Appraisal of Doctors, Patients and Caregivers Unmet Needs (IDEA), N=500 physicians and N=2.500 patients; Funding: Novartis GmbH.
- EDSP family genetic and genetic program (EDSP-FG, 1998-present, N=2.100, funding BMBF and NGF
- Early Developmental Stages of Psychopathology (EDSP): 1994-present, N=3.021 community subjects aged 14-24 at baseline); 4 waves, funding: BMBF
- Allocation in Substitution Treatments (COBRA/ASAT): 2002-present, 2.546 patients, 2 waves, funding: Schering-Plough, BMBF, application BMG pending
- Smoking and Nicotine Dependence Awareness Study (SNICAS): 2001-2006, 28.000 patients, 813 primary care sites; Funding: GSK and BMBF
- Depression 2000 and GAD-P: 2000-2005, 35.000 patients in over 800 primary care sites, funding: Organon, Wyeth
2. Somatic Health Studies:
- Renocardial Syndrome RCS - heart and kidney in patients in dialysis facilities - A nationwide clinical epidemiological cross-sectional study in dialysis facilities: N=200 physicians and N=1000 patients; Funding: Abbott GmbH.
- Severe Asthma: Prevalence and Current Treatment Needs (SAP-Needs), phase I: N=681 physicians and N=13,066 patients, phase II: N=157 physicians and N=570 patients; Funding: Novartis GmbH.
- Multiple Sclerosis Patients and their Caregivers Psychopathological and General Burden of Disease (MS Caregiver Burden), structured interview of N=400 multiple sclerosis patients and 400 care givers; Funding: Norvartis GmbH.
- Expert Based Survey to Investigate the Health Care Situation of Patients with Multiple Sclerosis (MS-Expert), N=2.000 multiple sclerosis healthcare provider, mail and telephone survey,; Funding: Novartis GmbH.
- Diabetes Cardiovascular Risk-Evaluation: Targets and Essential Data for Commitment of Treatment (DETECT): 2003-present, N=55.000, 3.795 primary care sites, 3 waves, funding: Pfizer GmbH.
- Hypertension and Diabetes Risk Screening and Awareness Study (HYDRA): 2001-2006, N=43.000, 1912 primary care Settings, funding: Sanofi Aventis GmbH.
- The German National Health Interview and Examination Survey - Mental health supplement (BGS): 1998-2005, N=4.181, Funding: BMBF